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ProPresenter will not talk to anything until you switch its network setting on. It is off when ProPresenter is installed, so this is a step you have to do.
1

In ProPresenter, turn the network setting on

Settings → Network, and switch it on.
2

Note the port number

It is on the same screen. Usually 1025.
3

In ScreenShepherd, open the setup tab

Under propresenter there are two boxes: address and port.Leave the address alone if ProPresenter is on this same Mac. Put your port number in the port box, and save.
4

Look for connected

A small badge shows connected when it has worked.

If ProPresenter is on a different Mac

Put that Mac’s address in the address box instead — something like 192.168.1.50. You can paste it with http:// on the front if that is what you copied; it is tidied up for you. To find the address, on the Mac running ProPresenter: System Settings → Network → Wi-Fi → Details. It is the IP address.
The first time, macOS asks whether ScreenShepherd may find devices on your network. Say yes. If you say no it will never connect, and nothing on screen will explain why — you have to turn it back on in System Settings → Privacy & Security → Local Network.
Both Macs must be on the same network. A guest wifi network usually blocks machines from seeing each other, so use the same one for both.

Troubleshooting

The message names the address it tried. Work through these in order:
  1. Is ProPresenter actually open — on that machine?
  2. Is Settings → Network still switched on there? It can get switched off, especially after a ProPresenter update.
  3. Does the port here match the port ProPresenter shows?
  4. If ProPresenter is on another Mac: are both on the same network, and did you allow local network access?
Different problem: it was working. Usually the other Mac went to sleep, or dropped off the wifi. It reconnects by itself once that machine is back.
Give it a few seconds. It does this by itself and usually sorts itself out.
That is almost always the microphone rather than ProPresenter. Go to The microphone and use check the microphone.
If ProPresenter was reinstalled or updated, check the network setting is still on and the port has not changed.